Integra Nutrition
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OUR GLUCOSAMINE FORMULATIONS

Benefits

 

þ Guaranteed Purity

þ Bioavailable D Form Stereoisomer

þ Added factors for enhanced control of inflammation

þ Added factors for enhanced control of pain

þ High absorption and utilization

þ Research

þ Clinically demonstrated effectiveness

þ Formulated for easy compliance

þ Pharmaceutical Manufacturing License

þ GMP (Good Manufacturing Practices

 

Successful treatment of osteoarthritis must effectively control pain and should slow down or reverse the progression of the degeneration. Biochemical and pharmacological data combined with animal and human studies demonstrate that glucosamine sulphate is capable of satisfying both of these criteria.

 

It has been suggested that the inability of the body to manufacture glucosamine is one of the major factors contributing to degenerative joint diseases such as osteoarthritis.

 

Conventional Therapy

 

Non-steroidal Anti-inflammatory Drugs (NSAID's), the most common therapy for arthritis, often causes gastrointestinal bleeding and can accelerate the destructive nature of osteoarthritis. Studies consistently show that compared to NSAID's, long-term reductions in pain are greater in patients receiving glucosamine sulphate. Unlike NSAID's, glucosamine is better tolerated and

has none of the gastrointestinal side effects.

 

Glucosamine Described

 

Glucosamine is the most fundamental building block required for biosynthesis of connective tissue, such as the cartilage found in joints. Glucosamine can be found in many different tissues in the body such as the surface of the cells, ligaments and tendons. Therapeutically, glucosamine is used to stimulate the biosynthesis of the glycosaminoglycans (GAG's) and the hyaluronic acid backbone needed for the formation of proteoglycans, compounds that comprise the structural matrix of joints. Glucosamine is also required for the formation of lubricants and protective agents such as mucin and mucous secretions. One of its key effects is to also stimulate the incorporation of sulfur into cartilage.

 

Studies have shown that up to 98% of ingested glucosamine sulphate is absorbed by the body.

 

D-Glucosamine Described

 

However, all glucosamine sulphate products are not the same. Most commercially available glucosamine products are of very low purity and generally contain both D and L stereoisomer forms of the glucosamine molecule. Commercially available products will normally contain D-glucosamine and L-glucosamine in an approximately 50/50 ratio. However, glucosamine exists and is incorporated in the body only as D-glucosamine. Hence the L-glucosamine sulphate is wasted. Since glucosamine is sold by weight, a capsule containing 500 mg of D-glucosamine provides twice the dose of bioavailable glucosamine when compared to an identical capsule consisting of regular D/L glucosamine sulphate.

 

Our Company

 

Integra Nutrition Inc. is the exclusive distributor of Alpha Science Laboratories products. We have been servicing the health care professional for five years. Our mission is to provide products of uncompromising quality with unquestionable integrity.

 

Alpha Science Laboratories is a pharmaceutical licensed manufacturer and as such has to meet the highest standards set out by governmental health agencies. This includes meeting the requirements of Good Manufacturing Practices (GMP).

 

Further, Alpha Science Laboratories also meets the highest standards set out by our natural health care clientele. All our products are 100% natural and contain no additives. Our products are regularly assayed for heavy metal contamination and a complete certificate of analysis verifies the purity and content of each ingredient.

 

Products

 

Arthriplex- D-Glucosamine Sulphate combined with the natural herbs Cat's Claw, Yucca, and Curcumin for enhanced pain control and anti-inflammatory effects. It also contains cellulase for increased breakdown and utilization of each herb.

 

MSM and D-Glucosamine Sulphate- D-Glucosamine Sulphate with added benefit of MSM for added control of pain and inflammation. D-Glucosamine/Chondroitin Sulphate D-Glucosamine Sulphate combined with Chondroitin Sulphate for added stimulation of joint regeneration.

 

References
  1. Biochemistry 2nd Edition Donald Voel & Judith Voel Page: 257-258
  2. Crolle G, D'Este E. Glucosamine sulphate for the management of arthrosis: a controlled clinical evaluation. Curr Med Res Opin 1980;7:104-109.
  3. D'Ambrosio ED, Casa B, Bompani R, et al. Glucosamine sulphate: a controlled clinical investigation in arthrosis. Pharmatherapeutica 1981;2:504-508.
  4. Drovanti A, Bignamini AA, Rovati AA. “Therapeutic activity of oral glucosamine sulphate in osteoarthritis: a placebo-controlled double-blind investigation.” Clin Ther, 1980;3:260-72.
  5. Forster KK, et al. “Longer-term treatment of mild-to-moderate osteoarthritis of the knee with glucosamine sulphate – a randomized, controlled, double-blind study.” Euro J Clin Pharmacol, 1996; 50: 542.
  6. Karzel K, Lee KJ. Effect of hexosamine derivatives on mesenchymal metabolic processes of in vitro cultured fetal bone explants. Z Rheumatol 1982;41:212-218.
  7. Lininger, SW. The Natural Pharmac. 1st ed. Rocklin CA; Prima Publishing, 1998.
  8. Murray MT. Glucosamine sulphate: effective osteoarthritis treatment. Amer J Nat Med 1994; Sept:10-14.
  9. Pugalte JM, Llavore EP, Ylecupidez FR. “Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthritis.” Curr Med Res Opin, 1980;7: 110-14.
  10. Pujalte JM, Llavore EP, Ylescupidez FR. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin 1980;2:110-14.
  11. Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulphate versus ibuprofen in patients with knee osteoarthritis. Arzneim Forsch 1998;48:469-74
  12. Rovati LC. Clinical research in osteoarthritis: design and results of short-term and long-term trials with disease modifying drugs. Int J Tissue React 1992;14:243-251.
  13. Setnikar I, Palumbo R, Canali S, Zanolo G. Pharmacokinetics of glucosamine in man. Arzneim Forsch 1993;43:1109-1113.
  14. Setnikar I, Giachetti C, Zanolo G. Pharmacokinetics of glucosamine in the dog and in man. Arzneim Forsch 1986;36:729-733.
  15. Setnikar I, Giachetti C, Zanolo G. Absorption, distribution, and excretion of radioactivity after a single intravenous or oral administration of glucosamine to the rat. Pharmatherapeutica 1984;3:538-550.
  16. Setnikar I, Cereda R, Pacini MA, Revel L. Antireactive properties of glucosamine sulphate. Arzneim Forsch 1991;41:157-161.
  17. Tapadinhas MJ, Rivera IC, Bignamini AA. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherapeutica 1982;3:157-168.
  18. Vaz AL. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 1982;8:145-149.
  19. Vaz AL. “Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthritis of the knee in out-patients.” Curr Med Res Opin, 1982;8: 145-49.
  20. Virkamaki A, Daniels MC, Hamalainen S, et al. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues. Endocrinology 1997;138:2501-7.


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